A common compound: 67442-07-3, name is 2-Chloro-N-methoxy-N-methylacetamide, belongs to amides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 67442-07-3
To a THF solution of (RS)-1-bromo-2-mehyloxy-3-(1-methyloxyheptyl)benzene (2, 6.3 g, 20 mmol) obtained in the second step was added dropwise 2M isopropylmagnesium chloride (20 mL). 2-Chloro-N-methyloxy-N-methylacetamide (5.5 g) was added thereto, and the mixture was stirred at room temperature. To the reaction solution was added aqueous hydrochloride acid solution, followed by extraction with ethyl acetate. After the solvent was distilled off, the residue was purified by silica gel chromatography to obtain 2.80 g of a compound (3). NMR (CDCl3) delta ppm: 7.58 – 7.61 (m, 1H), 7.51 – 7.54 (m, 1H), 7.22 – 7.27 (m, 1H), 4.72 (dd, 2H, J = 20.8 Hz, 15.9 Hz), 4.54 (dd, 1H, J = 8.1 Hz, 4.8 Hz), 3.78 (s, 3H), 3.22 (s, 3H), 1.14 – 1.77 (m, 10H), 0.84 – 0.90 ( m, 3H)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 67442-07-3, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Shionogi&Co., Ltd.; EP2184279; (2010); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics