On July 31, 1981, Kumar, Kamal; Bindal, Mahesh C.; Singh, Prithvi; Gupta, Satya P. published an article.SDS of cas: 97-09-6 The title of the article was Effect of molecular size on carbonic anhydrase inhibition by sulfonamides. And the article contained the following:
Mol. size plays an important role in carbonic anhydrase inhibition by sulfonamides. Significant correlation is obtained between the inhibitory power of meta-substituted analogs and the van der Waals volume of the substituents. This provides a theor. basis for mapping the active sites in the enzyme and determining the nature of sulfonamide-receptor binding. It is inferred that, in addition to the well-known binding of the sulfamyl group with the Zn2+ ion of the enzyme, the meta substituent of sulfonamides interacts with some secondary binding site; this interaction is argued to be of van der Waals type. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).SDS of cas: 97-09-6
The Article related to carbonic anhydrase inhibition sulfonamide mol volume, Enzymes: Substrates-Cofactors-Inhibitors-Activators-Coenzymes-Products and other aspects.SDS of cas: 97-09-6
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