Fadavi, Abdulhamid et al. published their research in Comptes Rendus Chimie in 2018 |CAS: 27115-50-0

The Article related to azlactone preparation, carboxylic acid glycine aldehyde vilsmeier multicomponent, oxazolone preparation, glycine carboxylic acid vilsmeier multicomponent, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Related Products of 27115-50-0

On January 31, 2018, Fadavi, Abdulhamid; Zarei, Maaroof published an article.Related Products of 27115-50-0 The title of the article was One-pot Vilsmeier reagent-mediated multicomponent reaction: A direct synthesis of oxazolones and Erlenmeyer azlactones from carboxylic acids. And the article contained the following:

N-Acylation of glycine with carboxylic acids RC(O)OH [R = C6H5, 4-pyridyl, 2-naphthyl, CH3CH=CH, etc.] was carried out by using the Vilsmeier reagent. The resulting N-acyl-α-amino acids RC(O)NHCH2C(O)OH were subsequently cyclodehydrated into oxazol-5-ones I via the Vilsmeier reagent. Finally, treatment of oxazol-5-ones I with aldehydes R1CHO [R1 = CH3, C6H5, 2-furyl, etc.] in the presence of the Vilsmeier reagent delivered Erlenmeyer azlactones II. By combining these steps, using the Vilsmeier reagent allowed direct one-pot conversion of carboxylic acids RC(O)OH into oxazol-5-ones I and direct one-pot conversion of carboxylic acids RC(O)OH into Erlenmeyer azlactones in the presence of aldehydes R1CHO. These Vilsmeier reagent-mediated multicomponent reactions proceeded smoothly in reasonable chem. yields at room temperature The chem. structure of the title compounds I and II was confirmed by spectral data. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Related Products of 27115-50-0

The Article related to azlactone preparation, carboxylic acid glycine aldehyde vilsmeier multicomponent, oxazolone preparation, glycine carboxylic acid vilsmeier multicomponent, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Related Products of 27115-50-0

Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics