On April 19, 2017, Ma, Xiaodong; Song, Anran; Wang, Luhong; Liu, He; Zhang, Baojing; Wang, Changyuan; Meng, Qiang; Shu, Xiaohong; Zhen, Yuhong; Liu, Kexin published a patent.Category: amides-buliding-blocks The title of the patent was Preparation of distyryl pyrimidine derivatives as antitumor agents. And the patent contained the following:
Title compounds I [wherein X = NH or O; R1 = Cl, F, CF3, or NO2; R2 = H, Me, OMe, or CN; R3 = (R4)n, n is 1 to 4, R4 is H, Me, OMe, OH, F, Cl, or Br], and their pharmaceutically acceptable salts thereof, were prepared as EGFR inhibitors useful as antitumor agents. Thus, the invention compound II was prepared and gave an EGFR inhibition IC50 value of 51.34nmmol. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Category: amides-buliding-blocks
The Article related to distyryl pyrimidine antitumor egfr preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics