On May 4, 2017, Xu, Xuenong published a patent.Related Products of 16230-24-3 The title of the patent was Process for preparation of Rociletinib. And the patent contained the following:
This invention discloses a process for the preparation of Rociletinib, which comprises condensation reaction of 5-trifluoromethyluracil with 4-(4-acetyl-piperazin-1-yl)-2-methoxyaniline to obtain 2-[[4-(4-acetyl-piperazin-1-yl)-2-methoxyphenyl]amino]-5-(trifluoromethyl)-pyrimidin-4-one, followed by halogenation to obtain 2-[[4-(4-acetyl-piperazin-1-yl)-2-methoxy phenyl]amino]-5-(trifluoromethyl)-4-halo-pyrimidine, and amination with N-(3-aminophenyl)-2-acrylamide to obtain title product. The process has the advantages of easily available raw materials, simple procedures, low cost, etc. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Related Products of 16230-24-3
The Article related to preparation rociletinib condensation reaction halogenation amination, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Related Products of 16230-24-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics