On April 17, 2020, Xiao, Cheng; Li, Si; Ma, Xiaodong; Chen, Lixue; Zheng, Xu; Wang, Changyuan published a patent.Application In Synthesis of N-(3-Aminophenyl)acrylamide The title of the patent was Azole-substituted pyrimidine derivative, its pharmaceutical composition, and its application in treatment of tumor. And the patent contained the following:
The invention relates to azole-substituted pyrimidine derivative of formula I as Bruton’s tyrosine kinase inhibitor useful in treatment of leukemia and its preparation Compounds I, wherein R1 and R2 are independently H, C1-6 alkyl or C3-8 cycloalkyl; R3 is halo; their stereoisomers, geometry isomers, tautomers, N-oxides, metabolite, hydrates, solvates, pharmaceutical salts, or prodrug, are claimed. Therefore, the inventive compound can be applied in the treatment of tumors, especially chronic lymphocytic leukemia, acute lymphocytic leukemia, chronic myeloid leukemia and acute myeloid leukemia. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Application In Synthesis of N-(3-Aminophenyl)acrylamide
The Article related to azole pyrimidine preparation bruton tyrosine kinase inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application In Synthesis of N-(3-Aminophenyl)acrylamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics