On July 3, 2008, Aissaoui, Hamed; Boss, Christoph; Gude, Markus; Koberstein, Ralf; Sifferlen, Thierry published a patent.HPLC of Formula: 65645-88-7 The title of the patent was Preparation of 5,6,7,8-tetrahydro-imidazo[1,5-a]pyrazine derivatives as orexin receptor antagonists. And the patent contained the following:
Title compounds represented by the formula I [wherein X = CH2 or O; R1 = independently phenyl; R2 = alkyl, alkenyl, halo, etc.; R3 = alkyl, alkoxymethyl or halo; R4 = alkyl; and pharmaceutically acceptable salts thereof] were prepared as orexin (OX) receptor antagonists. For example, II was provided in a multi-step synthesis starting from Knoevenagel condensation of 3,4-dimethylbenzaldehyde with malonic acid. I showed antagonistic activity on OX1 and OX2 receptors in intracellular calcium measurements. The experimental process involved the reaction of (S)-2-Hydroxy-N-methyl-2-phenylacetamide(cas: 65645-88-7).HPLC of Formula: 65645-88-7
The Article related to tetrahydroimidazopyrazine preparation orexin receptor antagonists, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.HPLC of Formula: 65645-88-7
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics