On October 3, 2019, Bi, Yingzhi; Dorsey, Bruce D.; Fan, Yi; Moore, Christopher Brooks; Nguyen, Duyan published a patent.Product Details of 5455-98-1 The title of the patent was Preparation of substituted 1,1′-biphenyl compounds and analogues thereof, and methods for using them for treatment of HBV and HDV infections. And the patent contained the following:
The invention is related to the preparation of compounds I [X1 = CH, N; X2 = R2a = OCH2**, CH2O**, CONH**, NHCO**, wherein the bond marked with ** is to the Ph ring carbon marked with *; R1a, R1b = independently H, alkyl, alkoxy, CN, halo, haloalkyl; R1c = H, alkyl, OH, alkoxy optionally substituted; R2a = alkyl, alkoxy, (CH2)1-3(optionally substituted phenyl), etc.; R3a = CHO, COOH and derivatives, CONH2 and derivatives, etc.; R4a = halo, CN, alkyl], including substituted 3,3′-bis(phenoxymethyl)-1,1′-biphenyl compounds and their analogs, their salts, solvates, geometric isomers, stereoisomers, tautomers or any mixtures thereof, and compositions comprising them, that can be used to treat or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. Thus, II was prepared from (2-methyl-3-phenylphenyl)methanol using 2,4-dihydroxybenzaldehyde, 3-(bromomethyl)benzonitrile and ethane-1,2-diamine. II displayed an IC50 of 0.28 in a PD-L1 HTRF assay. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Product Details of 5455-98-1
The Article related to biphenyl analog preparation pd1 pdl1 inhibitor antiviral hbv hdv, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Product Details of 5455-98-1
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics