On June 29, 2020, Zhang, Guofu; Cui, Yin; Zhao, Yiyong; Cui, Yunqiang; Bao, Shenxiao; Ding, Chengrong published an article.Category: amides-buliding-blocks The title of the article was A Practical Approach to Ureas and Thiocarbamates: SO2F2-Promoted Lossen Rearrangement of Hydroxamic Acid. And the article contained the following:
A simple, mild and practical method for the synthesis of sym. urea ArNHC(O)NHAr (Ar = C6H5, 1-naphthyl, 2-pyridyl, etc.) via Lossen rearrangement promoted by SO2F2, which achieves the conversion from hydroxamic acid ArC(O)NHOH to sym. urea in high selectivity and provides a new method for facile initiation of Lossen rearrangement has been described. Meanwhile, the reaction within amines R1NHR2 (R1 = 4-CH3OC6H4, 4-ClC6H4, C6H5CH2; R2 = H, Me) or thiols like 4-methylbenzene-1-thiol and phenylmethanethiol also provide the efficient synthetic strategy towards unsym. ureas C6H5NHC(O)NR1R2 or thiocarbamates like S-(p-tolyl) phenylcarbamothioate and S-benzyl phenylcarbamothioate. Significant for gram-scale application, the desired product on gram-scale by filtration without further purifn was afforded. A plausible mechanism which is supported by control exptl. and spectral data is proposed. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Category: amides-buliding-blocks
The Article related to urea preparation, hydroxamic acid lossen rearrangement, amine hydroxamic acid lossen rearrangement, thiocarbamate preparation, thiol hydroxamic acid lossen rearrangement, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics