Mekky, Ahmed E. M.; Sanad, Sherif M. H.; Said, Ahmed Y.; Elneairy, Mohamed A. A. published an article in 2020, the title of the article was Synthesis, cytotoxicity, in-vitro antibacterial screening and in-silico study of novel thieno[2,3-b]pyridines as potential pim-1 inhibitors.Quality Control of 2-Chloroacetamide And the article contains the following content:
A novel series of thieno[2,3-b]pyridines I [R = Me, MeO; R1 = acetyl, ethoxycarbonyl, aminocarbonyl, etc.] was prepared via an one-step protocol in excellent yields. The protocol involved the reaction of pyridine-2(1H)-thiones I with the appropriate halogen containing reagents in ethanolic sodium ethoxide solution under stirring at 80°C for 2 h. The new thienopyridines were screened against different bacterial and fungal strains. Thieno[2,3-b]pyridine-2-carboxylate I [R = Me; R1 = ethoxycarbonyl] showed the most effective antibacterial activities against each of Staphylococcus aureus and Escherichia coli with MIC/MBC values of 9.9/19.8 and 19.8/39.5μM, resp., when compared with Ciprofloxacin. I [R = Me; R1 = ethoxycarbonyl] was the most effective compound against MRSA with inhibition zone of 16.2 ± 0.6 mm, when compared with Gentamicin. Moreover, I [R = Me; R1 = ethoxycarbonyl] exhibited the best cytotoxic activity against each of HEPG2 and MCF-7 cell lines with IC50 values of 25.7 and 30.53μM, resp., when compared with Doxorubicin. The in-silico study was performed to predict the capability of new thienopyridines as potential inhibitors of pim-1 kinase. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Quality Control of 2-Chloroacetamide
The Article related to thienopyridine preparation antibacterial activity antitumor pim kinase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Quality Control of 2-Chloroacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics