On July 13, 2020, Sanad, Sherif M. H.; Mekky, Ahmed E. M. published an article.Synthetic Route of 79-07-2 The title of the article was Novel Nicotinonitriles and Thieno[2,3-b]pyridines as Potent Biofilm and COX-2 Inhibitors: Synthesis, In Vitro and In Silico Studies. And the article contained the following:
(Cyano)diaryl-substituted pyridine-2(1H)-thiones were used to prepare two novel series of nicotinonitriles I (R1 = 2-thienyl, R2 = 4-ClC6H4; R1 = 1,3-benzodioxol-5-yl, R2 = 2-thienyl; R1 = 3,5-dibromo-4-ethoxyphenyl, R2 = 4-MeC6H4; R3 = MeCO, CN, H2NCO, 4-ClC6H4CO) and thieno[2,3-b]pyridines II (R1-R3 as above) using piperazine as an eco-friendly catalyst under ultrasonic irradiation The in vitro antibacterial activities of both series were estimated against different Gram-pos. and neg. bacterial strains. Moreover, the most potent antibacterial derivatives were subjected to further evaluation of their cytotoxic activity against HEPG2 and MCF-7 cell lines as well as their capability to inhibit COX-2 enzyme. The compound I (R1 = 1,3-benzodioxol-5-yl; R2 = 2-thienyl; R3 = H2NCO) gave the least MIC/MBC values of 4.8/9.6, 4.8/9.6 and 9.6/19.7μM against each of Staphylococcus aureus, Escherichia coli and Streptococcus mutans, resp., when compared with Ciprofloxacin. This compound I also showed the best biofilm inhibition activities with IC50 values in the range of 5.2-7.3μM against S. aureus, S. mutans and E. coli bacterial strains when compared with Ciprofloxacin, the best cytotoxic activity against HEPG2 and MCF-7 cell lines with IC50 of 23.9 and 29.8μM, resp., when compared with Doxorubicin and revealed nearly inhibition activity equipotent to Celecoxib with IC50 of 0.12μM. The in silico study was performed to predict the capability of the novel nicotinonitriles and thienopyridines as potent inhibitors of COX-2 enzyme. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Synthetic Route of 79-07-2
The Article related to nicotinonitrile thienopyridine preparation antibacterial antitumor antibiofilm cox2 inhibitor human, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Synthetic Route of 79-07-2
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