Leimbacher, Markus; Zhang, Yixin; Mannocci, Luca; Stravs, Michael; Geppert, Tim; Scheuermann, Joerg; Schneider, Gisbert; Neri, Dario published an article in 2012, the title of the article was Discovery of Small-Molecule Interleukin-2 Inhibitors from a DNA-Encoded Chemical Library.Synthetic Route of 27115-50-0 And the article contains the following content:
Libraries of chem. compounds individually coupled to encoding DNA tags (DNA-encoded chem. libraries) hold promise to facilitate exceptionally efficient ligand discovery. We constructed a high-quality DNA-encoded chem. library comprising 30 000 drug-like compounds; this was screened in 170 different affinity capture experiments High-throughput sequencing allowed the evaluation of 120 million DNA codes for a systematic anal. of selection strategies and statistically robust identification of binding mols. Selections performed against the tumor-associated antigen carbonic anhydrase IX (CA IX) and the pro-inflammatory cytokine interleukin-2 (IL-2) yielded potent inhibitors with exquisite target specificity. The binding mode of the revealed pharmacophore against IL-2 was confirmed by mol. docking. Our findings suggest that DNA-encoded chem. libraries allow the facile identification of drug-like ligands principally to any protein of choice, including mols. capable of disrupting high-affinity protein-protein interactions. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Synthetic Route of 27115-50-0
The Article related to dna encoded chem library drug discovery protein ligand, interleukin 2 inhibitor dna encoded chem library, tumor antigen carbonic anhydrase ix inhibitor dna encoded library and other aspects.Synthetic Route of 27115-50-0
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