Xue, Weifeng; Yang, Chunguang; Liu, Mengyao; Lin, Xiaomei; Wang, Mei; Wang, Xiaowen published an article in 2022, the title of the article was Metabolomics Approach on Non-Targeted Screening of 50 PPCPs in Lettuce and Maize.Name: N-((4-Aminophenyl)sulfonyl)acetamide And the article contains the following content:
The metabolomics approach has proved to be promising in achieving non-targeted screening for those unknown and unexpected (U&U) contaminants in foods, but data anal. is often the bottleneck of the approach. In this study, a novel metabolomics anal. method via seeking marker compounds in 50 pharmaceutical and personal care products (PPCPs) as U&U contaminants spiked into lettuce and maize matrixes was developed, based on ultrahigh-performance liquid chromatog.-tandem mass spectrometer (UHPLC-MS/MS) output results. Three concentration groups (20, 50 and 100 ng mL-1) to simulate the control and exptl. groups applied in the traditional metabolomics anal. were designed to discover marker compounds, for which multivariate and univariate anal. were adopted. In multivariate anal., each concentration group showed obvious separation from other two groups in principal component anal. (PCA) and orthogonal partial least squares discriminant anal. (OPLS-DA) plots, providing the possibility to discern marker compounds among groups. Parameters including S-plot, permutation test and variable importance in projection (VIP) in OPLS-DA were used for screening and identification of marker compounds, which further underwent pairwise t-test and fold change judgement for univariate anal. The results indicate that marker compounds on behalf of 50 PPCPs were all discovered in two plant matrixes, proving the excellent practicability of the metabolomics approach on non-targeted screening of various U&U PPCPs in plant-derived foods. The limits of detection (LODs) for 50 PPCPs were calculated to be 0.4∼2.0μg kg-1 and 0.3∼2.1μg kg-1 in lettuce and maize matrixes, resp. The experimental process involved the reaction of N-((4-Aminophenyl)sulfonyl)acetamide(cas: 144-80-9).Name: N-((4-Aminophenyl)sulfonyl)acetamide
The Article related to lettuce maize ppcps nontargeted screening metabolomics, marker compounds, metabolomics, non-targeted screening, pharmaceutical and personal care products, plant-derived food and other aspects.Name: N-((4-Aminophenyl)sulfonyl)acetamide
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