Zhu, Dongsheng; Guo, Haijun; Chang, Yu; Ni, Yun; Li, Lin; Zhang, Zhi-Min; Hao, Piliang; Xu, Yong; Ding, Ke; Li, Zhengqiu published an article in 2018, the title of the article was Cell- and Tissue-Based Proteome Profiling and Dual Imaging of Apoptosis Markers with Probes Derived from Venetoclax and Idasanutlin.Category: amides-buliding-blocks And the article contains the following content:
Venetoclax (ABT-199) and idasanutlin (RG7388) are efficient anticancer drugs targeting two essential apoptosis markers, Bcl-2 and MDM2, resp. Recent studies have shown that the combination of these two drugs leads to remarkable enhancement of anticancer efficacy, both in vitro and in vivo. In an attempt to disclose the relationships of their protein targets, competitive affinity-based proteome profiling coupled with bioimaging was employed to characterize their protein targets in the same cancer cell line and tumor tissue. A series of protein hits, including ITPR1, GSR, RER1, PDIA3, Apoa1, and Tnfrsf17 were simultaneously identified by pull-down/LC-MS/MS with the two sets of affinity-based probes. Dual imaging was successfully carried out, with the simultaneous detection of Bcl-2 and MDM2 expression in various cancer cells. This could facilitate the novel diagnostic and therapeutic strategies of dual targeting of Bcl-2/MDM2. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Category: amides-buliding-blocks
The Article related to proteomics imaging apoptosis marker venetoclax idasanutlin drug target, affinity-based probes, antitumor agents, apoptosis biomarkers, combination drugs, target identification and other aspects.Category: amides-buliding-blocks
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