On January 31, 2020, Rodriguez, Frederic; Saffon, Nathalie; Sammartino, Jose Camilla; Degiacomi, Giulia; Pasca, Maria Rosalia; Lherbet, Christian published an article.Safety of N-(3-Aminophenyl)acrylamide The title of the article was First triclosan-based macrocyclic inhibitors of InhA enzyme. And the article contained the following:
Two macrocyclic derivatives based on the triclosan frame were designed and synthesized as inhibitors of Mycobacterium tuberculosis InhA enzyme. One of the two mols. M02 displayed promising inhibitory activity against InhA enzyme with an IC50 of 4.7μM. Mol. docking studies of these two compounds were performed and confirmed that M02 was more efficient as inhibitor of InhA activity. These mols. are the first macrocyclic direct inhibitors of InhA enzyme able to bind into the substrate pocket. Furthermore, these biaryl ether compounds exhibited antitubercular activities comparable to that of triclosan against M. tuberculosis H37Rv strain. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Safety of N-(3-Aminophenyl)acrylamide
The Article related to preparation triclosan derivative macrocyclic inhibitor inha enzyme tuberculosis, enoyl-acp-reductase, inha, macrocycle, marchantin analogue, mycobacterium tuberculosis, triclosan and other aspects.Safety of N-(3-Aminophenyl)acrylamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics