On August 31, 2020, Sanad, Sherif M. H.; Mekky, Ahmed E. M. published an article.Recommanded Product: 2-Chloroacetamide The title of the article was Piperazine-mediated tandem synthesis of bis(thieno[2,3-b]pyridines): Versatile precursors for related fused [1,2,4]triazolo[4,3-a]pyrimidines. And the article contained the following:
In this study, the utility of bis(cyanoacetamides) as versatile precursors to the piperazine-mediated synthesis of a wide spectrum of bis(thieno[2,3-b]pyridine) derivatives, linked to aliphatic spacers via thioethers was reported. The proposed tandem protocol involved the reaction of bis(cyanoacetamides) with two equivalent of the appropriate cinnamonitriles in dioxane in the presence of six equivalent of piperazine was refluxed for 4 h which on further addition of halogen-containing reagents afforded bis(thieno[2,3-b]pyridine) derivatives I [Ar = 4-MeOC6H4, 4-ClC6H4; Y = CN, C(O)Me, C(O)NH2, etc.; Z = CH2, (CH2)3]. Compounds I were taken as a key intermediates and reacted with formic acid/acetic anhydride/carbon disulfide afforded bis(oxopyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine) derivatives II [R = H, Me; R1 = CH2, (CH2)3; Ar1 = 4-MeOC6H4, 4-ClC6H4] and III [R2 = CH2, (CH2)3]. Compounds III were reacted with the appropriate hydrazonyl chloride derivatives in dioxane in the presence of triethylamine afforded the corresponding bis([1,2,4]triazoles) with related fused pyridothienopyrimidine moiety IV [R3 = CH2, (CH2)3; Ar2 = Ph, 4-MeC6H4, 4-ClC6H4]. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Recommanded Product: 2-Chloroacetamide
The Article related to bis thienopyridine preparation, cyanoacetamide cinnamonitrile halogen reagent tandem four component piperazine mediated, oxopyridothienopyrimidine bis preparation, acetyl pyridothienotriazolopyrimidine bis preparation and other aspects.Recommanded Product: 2-Chloroacetamide
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