Reference of 316146-27-7, The chemical industry reduces the impact on the environment during synthesis 316146-27-7, name is N-(4-Bromophenyl)-3-phenylpropanamide, I believe this compound will play a more active role in future production and life.
b) Preparation of intermediate 11; The reaction was carried out twice. POCl3 (1.225 mol) was added dropwise at 10¡ãC to DMF (0.525 mol). Then intermediate 10 (0.175 mol) was added at room temperature. The mixture was stirred overnight at 8O0C, poured out on ice and extracted with CH2CI2. The organic layer was dried (MgSO4), filtered, and the solvent was evaporated. Yield: 77.62 g of intermediate 11 (67percent).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-(4-Bromophenyl)-3-phenylpropanamide, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; WO2007/435; (2007); A1;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics