On July 18, 2019, Hardy, Jeanne A.; Meka, Penchala Narasimhara published a patent.Formula: C9H10N2O The title of the patent was Preparation of furoxan-based compounds for treating neurodegenerative diseases. And the patent contained the following:
This invention relates to the title compounds I [R1 = H or aryl; R2 = H or aryl; X1 and X2 = (independently) N, N+-O- or CR3 (wherein R3 = H or alkyl and only one of X1 and X2 can be N+-O-); with the proviso] or pharmaceutically acceptable salts, polymorphs, prodrugs, solvates or clathrates thereof, as well as to pharmaceutical compositions comprising such compounds, and to methods for using such compounds/pharmaceutical compositions for treating neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and multiple sclerosis (MS). Over fifty compounds I were prepared E.g., a multi-step synthesis of II, starting from cyclohexanone, was described. A method for inhibiting caspase-6 with a compound that reacts with the sulhydryl group (SH) on cysteine 246 of caspase-6 was disclosed (no biol. data given). The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Formula: C9H10N2O
The Article related to furoxan derivative preparation neurodegenerative alzheimer’s parkinson’s huntington’s disease treatment, caspase 6 inhibitor furoxan derivative triazolobenzooxadiazole preparation, multiple sclerosis treatment furoxan derivative triazolobenzooxadiazole preparation and other aspects.Formula: C9H10N2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics