On March 22, 2021, Hu, Zhiyong; Wei, Xiao-Jing; Handelmann, Jens; Seitz, Ann-Katrin; Rodstein, Ilja; Gessner, Viktoria H.; Goossen, Lukas J. published an article.SDS of cas: 685-91-6 The title of the article was Coupling of Reformatsky reagents with aryl chlorides enabled by ylide-functionalized phosphine ligands. And the article contained the following:
The coupling of aryl chlorides with Reformatsky reagents is a desirable strategy for the construction of α-aryl esters but has so far been substantially limited in the substrate scope due to many challenges posed by various possible side reactions. This limitation has now been overcome by the tailoring of ylide-functionalized phosphines to fit the requirements of Negishi couplings. Record-setting activities were achieved in palladium-catalyzed arylations of organozinc reagents with aryl electrophiles using a cyclohexyl-YPhos ligand bearing an ortho-tolyl-substituent in the backbone. This highly electron-rich, bulky ligand enables the use of aryl chlorides in room temperature couplings of Reformatsky reagents. The reaction scope covers diversely functionalized arylacetic and arylpropionic acid derivatives Aryl bromides and chlorides can be converted selectively over triflate electrophiles, which permits consecutive coupling strategies. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).SDS of cas: 685-91-6
The Article related to aryl ester synthesis steric hindrance natural product drug, reformatsky reagent negishi coupling aryl chloride ylide phosphine ligand, arylation catalyst palladium aryl bromide chloride, reformatsky reagent, aryl chlorides, cross-coupling, phosphine ligands, selectivity and other aspects.SDS of cas: 685-91-6
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics