《Trans-Selective hydrocyanation of ynoates, ynones and ynoic acids catalyzed by nucleophilic phosphines》 was written by Schoemberg, Fritz; Peric, Milica; Meyer, Maximilian; Vilotijevic, Ivan. Formula: C4H9NO2This research focused ontrimethylsilyl cyanide phenyl propynoate methyldiphenylphosphine catalyst diastereoselective hydrocyanation; cyano phenyl acrylate regioselective preparation; trimethylsilanecarbonitrile phenyl propynoic acid methyldiphenylphosphine catalyst diastereoselective hydrocyanation; phenyl cyano acrylic acid regioselective preparation. The article conveys some information:
Trans-Selective hydrocyanation of ynoates and ynones in the presence of TMSCN and an alc. additive were catalyzed by nucleophilic phosphines. The trisubstituted E-olefin products of anti-addition of hydrogen cyanide to the alkyne were produced with high regio- and stereoselectivity. The alc. additive reacts with TMSCN to produce hydrogen cyanide in situ. Ynoic acids underwent the phosphine catalyzed hydrocyanation in the presence of TMSCN under aprotic conditions only. In these reactions, TMSCN reacted with the acid to generate hydrogen cyanide and the silyl ester which, unlike the acid, undergoes phosphine catalyzed hydrocyanation and gave the stereo-defined E-2-cyano-acrylic acids after work up.N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2) was used in this study.
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Formula: C4H9NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics