The author of 《Preparation of antibacterial polypeptides with different topologies and their antibacterial properties》 were Wang, Xiaodan; Yang, Fangping; Yang, Huawei; Zhang, Xu; Tang, Haoyu; Luan, Shifang. And the article was published in Biomaterials Science in 2022. Electric Literature of C11H22N2O4 The author mentioned the following in the article:
Antimicrobial peptides (AMPs) are attractive antimicrobial agents used to combat bacterial infections, and have been advanced to be one of the most promising alternatives to conventional antibiotics. They stand out for their attractive broad-spectrum activity, unmatched antibacterial mechanism that is not prone to develop drug resistance and diversified topologies, which can be fabricated with manifold amino acid blocks. In this study, using n-hexylamine and amine-terminated polyamidoamine dendrimers (Gx-PAMAM, x = 1-2) as initiators, a series of AMPs with linear and star-shaped topol. structures were constructed via the controllable ring-opening polymerization (ROP) of N-carboxyanhydrides (NCAs). The antibacterial performances of the tailored linear and star-shaped AMPs were comprehensively evaluated in both solution states and surface-bonded states. The results indicated that the star-shaped AMPs exhibited enhanced bactericidal activity against Gram-neg. E. coli and similar bactericidal activity against Gram-pos. S. aureus when compared with the linear AMPs. It is worth mentioning that star-shaped AMPs demonstrated a significantly faster bactericidal efficiency (completely killed bacteria within 5 min at a concentration of 2 x MIC for S. aureus) than their linear analogs (took 15 min to achieve the same effect). However, when the AMPs were immobilized to the surface, they similarly exhibited superior antibacterial activity and fast bactericidal efficiency towards S. aureus and E. coli in the case of the same surface grafting amount In addition, both the surfaces grafted with AMPs of different topologies demonstrated favorable biocompatibility in vitro. In addition to this study using H-Lys(Boc)-OH, there are many other studies that have used H-Lys(Boc)-OH(cas: 2418-95-3Electric Literature of C11H22N2O4) was used in this study.
H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Electric Literature of C11H22N2O4
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics