In 2015,Chemistry – A European Journal included an article by De, Dinesh; Neogi, Subhadip; Sanudo, E. Carolina; Bharadwaj, Parimal K.. Application In Synthesis of N-(Pyridin-4-yl)isonicotinamide. The article was titled 《Single-Crystal to Single-Crystal Linker Substitution, Linker Place Exchange, and Transmetalation Reactions in Interpenetrated Pillared-Bilayer Zinc(II) Metal-Organic Frameworks》. The information in the text is summarized as follows:
A 2-fold interpenetrated pillared-bilayer framework, {[Zn3(L)2(L2)(DMF)]·(18DMF)(6H2O)}n (1), was synthesized from the ligands tris(4′-carboxybiphenyl)amine (H3L) and 1,2-bis(4-pyridyl)ethylene (L2). The structure contains [Zn3(COO)6] secondary building units (SBUs), in which three ZnII ions are almost linear with carboxylate bridging. This framework undergoes reversible pillar linker substitution reactions at the terminal ZnII centers with three different dipyridyl linkers of different lengths to afford three daughter frameworks, 2-4. Frameworks 2-4 are interconvertible through reversible linker substitution reactions. Also, competitive linker-exchange experiments show preferential incorporation of linker L3 in the parent framework 1. The larger linker L5 does not undergo such substitution reactions and framework 5, which contains this linker, can be synthesized solvothermally as a 2-fold interpenetrated structure. When framework 5 is dipped in a solution of L3 in DMF, linker substitution takes place as before, but linker L5 now moves and diagonally binds two ZnII centers to afford 6 as a nonpenetrated single framework. This linker place exchange reaction is unprecedented. All of these reactions take place in a single-crystal to single-crystal (SC-SC) manner, and were observed directly through x-ray crystallog. Each 3D framework undergoes complete copper(II) transmetalation. After reading the article, we found that the author used N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Application In Synthesis of N-(Pyridin-4-yl)isonicotinamide)
N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Application In Synthesis of N-(Pyridin-4-yl)isonicotinamide The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics