Nevidalova, Hana; Michalcova, Lenka; Glatz, Zdenek published the artcile< Applicability of capillary electrophoresis-frontal analysis for displacement studies: Effect of several drugs on L-tryptophan and lidocaine binding to human serum albumin>, Synthetic Route of 94-20-2, the main research area is tryptophan lidocaine human serum albumin binding constant capillary electrophoresis; drug protein binding screening; binding constant; binding sites; capillary electrophoresis-frontal analysis; drug competition; human serum albumin.
The effective concentration of a drug in the blood, i.e. the concentration of a free drug in the blood, is influenced by the strength of drug binding onto plasma proteins. Besides its efficacy, these interactions subsequently influence the liberation, absorption, distribution, metabolism, excretion, and toxicol. properties of the drug. It is important to not only determine the binding strength and stoichiometry, but also the binding site of a drug on the plasma protein mol., because the co-administration of drugs with the same binding site can affect the above-mentioned concentration and as a result the pharmacol. behavior of the drugs and lead to side effects caused by the change in free drug concentration, its toxicity. In this study, the binding characteristics of six drugs with human serum albumin, the most abundant protein in human plasma, were determined by capillary electrophoresis-frontal anal., and the obtained values of binding parameters were compared with the literature data. The effect of several drugs and site markers on the binding of L-tryptophan and lidocaine to human serum albumin was investigated in subsequent displacement studies which thus demonstrated the usability of capillary electrophoresis as an automated high-throughput screening method for drug-protein binding studies.
Journal of Separation Science published new progress about Capillary electrophoresis. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Synthetic Route of 94-20-2.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics