Related Products of 64479-78-3On March 8, 2012, Li, Rongshi; Martin, Mathew P.; Liu, Yan; Wang, Binglin; Patel, Ronil A.; Zhu, Jin-Yi; Sun, Nan; Pireddu, Roberta; Lawrence, Nicholas J.; Li, Jiannong; Haura, Eric B.; Sung, Shen-Shu; Guida, Wayne C.; Schonbrunn, Ernst; Sebti, Said M. published an article in Journal of Medicinal Chemistry. The article was 《Fragment-Based and Structure-Guided Discovery and Optimization of Rho Kinase Inhibitors》. The article mentions the following:
Using high concentration biochem. assays and fragment-based screening assisted by structure-guided design, we discovered a novel class of Rho-kinase inhibitors. Compound 18 (I) was equipotent for ROCK1 (IC50 = 650 nM) and ROCK2 (IC50 = 670 nM), whereas compound 24 was more selective for ROCK2 (IC50 = 100 nM) over ROCK1 (IC50 = 1690 nM). The crystal structure of the compound 18-ROCK1 complex revealed that 18 is a type 1 inhibitor that binds the hinge region in the ATP binding site. Compounds 18 and 24 inhibited potently the phosphorylation of the ROCK substrate MLC2 in intact human breast cancer cells. In the experiment, the researchers used N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3Related Products of 64479-78-3)
N-(Pyridin-4-yl)isonicotinamide(cas: 64479-78-3) belongs to amides.Related Products of 64479-78-3 The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics