Avadhani, Anusha; Iniyavan, Pethaperumal; Kumar, Yogendra; Ila, Hiriyakkanavar published their research in Journal of Organic Chemistry in 2021. The article was titled 《Single-Pot Preparation of 4-Amino-2-(het)aryl-5-Substituted Thiazoles Employing Functionalized Dithioesters as Thiocarbonyl Precursors》.Name: 2-Bromoacetamide The article contains the following contents:
An effective, diversity oriented, one-pot reaction of 4-amino-2-(het)aryl/alkyl-5-functionalized thiazoles was disclosed, utilizing aryl/heteroaryl/alkyl dithioesters as thiocarbonyl coupling partners in a modified Thorpe-Ziegler type cyclization. The reaction proceeds at room temperature, under mild conditions, in excellent yields, displayed broad functional group compatibility at 2 and 5 positions of thiazoles. This synthetic strategy was further expanded for the one-pot construction of two highly potent tubulin polymerization inhibitors, i.e., 2-(het)aryl-4-amino-5-(3,4,5-trimethoxyaroyl) thiazoles, in high yields. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8Name: 2-Bromoacetamide)
2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Name: 2-Bromoacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics