《Copper(I)-mediated denitrogenative macrocyclization for the synthesis of cyclic α3β-tetrapeptide analogs》 was published in Chemistry – An Asian Journal in 2017. These research results belong to Chen, Chun-Chi; Wang, Sheng-Fu; Su, Yung-Yu; Lin, Yuya A.; Lin, Po-Chiao. Related Products of 87694-50-6 The article mentions the following:
A copper(I)-mediated denitrogenative reaction has been successfully developed for the preparation of cyclic tetrapeptides. The key reactive intermediate, ketenimine, triggers intramol. cyclization through attack of the terminal amine group to generate an internal β-amino acid with an amidine linkage. The chem. developed herein provides a new synthetic route for the preparation of cyclic α3β-tetrapeptide analogs that contain important biol. properties and results in rich structural information being obtained for conformational studies. With the success of this copper(I)-catalyzed macrocyclization, two histone deacetylase inhibitor analogs consisting of the cyclic α3β-tetrapeptide framework have been successfully synthesized. In addition to this study using (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide, there are many other studies that have used (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Related Products of 87694-50-6) was used in this study.
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides.Related Products of 87694-50-6 Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics