Reference of 207405-68-3, The chemical industry reduces the impact on the environment during synthesis 207405-68-3, name is tert-Butyl endo-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate, I believe this compound will play a more active role in future production and life.
General procedure: To the solution of compound 13 (0.11 g, 0.25 mmol) and bicyclicamine (0.38 mmol) in THF (3 mL) was added DIPEA (0.38 mmol). Afterstirred at R.T. for 1 h, the reaction mixture was diluted with EtOAc,washed with brine, dried over MgSO4, and evaporated. The residue waspurified by column chromatography to give the product.4.1.6. tert-butyl (endo)-3-((2,6-dichloro-8-((2-fluoro-4-(methylsulfonyl)phenyl)amino)pyrimido[5,4-d]pyrimidin-4-yl)amino)-8-azabicyclo[3.2.1]octane-8-carboxylate (14a)Yellow solid, 32% yield. 1H NMR (300 MHz, CDCl3) delta (ppm): 9.12(d, J=3.2 Hz, 1H), 8.95 (t, J=8.1 Hz, 1H), 7.80 (m, 2H), 7.45 (d,J=7.7 Hz, 1H), 4.50-4.20 (m, 3H), 3.10 (s, 3H), 2.50-2.10 (m, 4H),2.00-1.80 (m, 4H), 1.50 (s, 9H). HRMS-ESI (m/z) calcd forC25H28Cl2FN7O4S [M+Na]+: 634.1182, found 634.1234
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, tert-Butyl endo-3-amino-8-azabicyclo[3.2.1]octane-8-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Fang, Yuanying; Xu, Jun; Li, Zhifeng; Yang, Zunhua; Xiong, Lijuan; Jin, Yi; Wang, Qi; Xie, Saisai; Zhu, Wufu; Chang, Sheng; Bioorganic and Medicinal Chemistry; vol. 26; 14; (2018); p. 4080 – 4087;,
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