In 2015,Ikubo, Masaya; Inoue, Asuka; Nakamura, Sho; Jung, Sejin; Sayama, Misa; Otani, Yuko; Uwamizu, Akiharu; Suzuki, Keisuke; Kishi, Takayuki; Shuto, Akira; Ishiguro, Jun; Okudaira, Michiyo; Kano, Kuniyuki; Makide, Kumiko; Aoki, Junken; Ohwada, Tomohiko published 《Structure-Activity Relationships of Lysophosphatidylserine Analogs as Agonists of G-Protein-Coupled Receptors GPR34, P2Y10, and GPR174》.Journal of Medicinal Chemistry published the findings.HPLC of Formula: 71432-55-8 The information in the text is summarized as follows:
Lysophosphatidylserine (LysoPS) is an endogenous lipid mediator generated by hydrolysis of membrane phospholipid phosphatidylserine. Recent ligand screening of orphan G-protein-coupled receptors (GPCRs) identified two LysoPS-specific human GPCRs, namely, P2Y10 (LPS2) and GPR174 (LPS3), which, together with previously reported GPR34 (LPS1), comprise a LysoPS receptor family. Herein, the authors examined the structure-activity relationships of a series of synthetic LysoPS analogs toward these recently deorphanized LysoPS receptors, based on the idea that LysoPS can be regarded as consisting of distinct modules (fatty acid, glycerol, and L-serine) connected by phosphodiester and ester linkages. Starting from the endogenous ligand (1-oleoyl-LysoPS), the authors optimized the structure of each module and the ester linkage. Accordingly, the authors identified some structural requirements of each module for potency and for receptor subtype selectivity. Further assembly of individually structure-optimized modules yielded a series of potent and LysoPS receptor subtype-selective agonists, particularly for P2Y10 and GPR174. In addition to this study using tert-Butyl N,N’-diisopropylcarbamimidate, there are many other studies that have used tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8HPLC of Formula: 71432-55-8) was used in this study.
tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.HPLC of Formula: 71432-55-8
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics