In 2010,Sammet, Benedikt; Bogner, Tobias; Nahrwold, Markus; Weiss, Christine; Sewald, Norbert published 《Approaches for the Synthesis of Functionalized Cryptophycins》.Journal of Organic Chemistry published the findings.Recommanded Product: tert-Butyl N,N’-diisopropylcarbamimidate The information in the text is summarized as follows:
The first syntheses of bioactive cryptophycins functionalized at unit D were accomplished in a one-pot Staudinger reduction/cyclization step. An azido precursor for the lower part of the backbone was introduced to minimize protective group chem. and enable a very convenient synthesis of cryptophycin-52 and unit D cryptophycin analogs containing an ester or a free carboxylic acid for bioconjugations. Both new cryptophycin derivatives show high biol. activity in cytotoxicity assays. The results came from multiple reactions, including the reaction of tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Recommanded Product: tert-Butyl N,N’-diisopropylcarbamimidate)
tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Recommanded Product: tert-Butyl N,N’-diisopropylcarbamimidate
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics