Monty, Olivier B. C.; Nyshadham, Pranavanand; Bohren, Kurt M.; Palaniappan, Murugesan; Matzuk, Martin M.; Young, Damian W.; Simmons, Nicholas published an article on February 10 ,2020. The article was titled 《Homogeneous and Functional Group Tolerant Ring-Closing Metathesis for DNA-Encoded Chemical Libraries》, and you may find the article in ACS Combinatorial Science.Reference of H-Lys(Boc)-OH The information in the text is summarized as follows:
Reaction heterogeneity, poor pH control, and catalyst decomposition in the ring-closing metathesis (RCM) of DNA-chem. conjugates lead to poor yields of the cyclized products. Herein we address these issues with a RCM reaction system that includes a novel aqueous solvent combination to enable reaction homogeneity, an acidic buffer system which masks traditionally problematic functional groups, and a decomposition-resistant catalyst which maximizes conversion to the cyclized product. Addnl., we provide a systematic study of the substrate scope of the on-DNA RCM reaction, a demonstration of its applicability to a single-substrate DNA-encoded chem. library that includes sequencing anal., and the first successful stapling of an unprotected on-DNA [i, i+4] peptide.H-Lys(Boc)-OH(cas: 2418-95-3Reference of H-Lys(Boc)-OH) was used in this study.
H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Reference of H-Lys(Boc)-OH
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics