Electric Literature of C13H26N2O4On November 30, 2014 ,《Design, Synthesis and Biological Evaluation of Peptidyl Epoxyketone Proteasome Inhibitors Composed of β-amino Acids》 appeared in Chemical Biology & Drug Design. The author of the article were Zhang, Jiankang; Han, Mengmeng; Ma, Xiaodong; Xu, Lei; Cao, Jiayi; Zhou, Yubo; Li, Jia; Liu, Tao; Hu, Yongzhou. The article conveys some information:
A series of novel di- and tripeptidyl epoxyketone derivatives composed of β-amino acids were designed, synthesized and evaluated for their proteasome inhibitory activities and antiproliferation activities against two multiple myeloma cell lines RPMI 8226 and NCI-H929 and normal cells (peripheral blood mononucleated cells). Among these tested compounds, tripeptidyl analogs showed much more potent activities than dipeptides, and four tripeptidyl compounds exhibited proteasome inhibitory activities with IC50 values ranging from 0.97±0.05 to 1.85±0.11 μm. In addition, all the four compounds showed antiproliferation activities with IC50 values at low micromolar levels against two multiple myeloma cell lines and weak activities against normal cells. Furthermore, Western blot anal. was performed to verify the proteasome inhibition induced by compounds I [R = 4-FC6H4] and I [R = 4-MeOC6H4]. All the exptl. results validated that the β-amino acid building block has the potential for the development of proteasome inhibitors. In addition to this study using (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide, there are many other studies that have used (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Electric Literature of C13H26N2O4) was used in this study.
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides.Electric Literature of C13H26N2O4 The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics