Dong, Pei; Li, Zhaojing; Liu, Xiaohua; Dong, Shunxi; Feng, Xiaoming published the artcile< Asymmetric synthesis of polycyclic spiroindolines via the Dy-catalyzed cascade reaction of 3-(2-isocyanoethyl)indoles with aziridines>, Application of C6H6ClNO2S, the main research area is isocyanoethyl indole aziridine dysprosium catalyst enantioselective tandem reaction; phenyltetrahydropyrrolo pyridoindole dicarboxylate preparation.
Herein, a tailored strategy to access such compounds through an asym. ring-opening/Friedel-Crafts/Mannich/desulfonylation cascade reaction was reported. In the presence of the N,N’-dioxide-Dy(III) complex, various 2,2′-diester aziridines and 3-(2-isocyanoethyl)indoles were converted into tetracyclic spiroindolines in a highly diastereo- and enantioselective manner (41 examples, up to 88% yield, 97% ee). On the basis of the absolute configuration of the product and previous works, a possible catalytic cycle was proposed to understand the origin of stereocontrol.
Organic Chemistry Frontiers published new progress about Aziridines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Application of C6H6ClNO2S.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics