Name: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamideOn June 15, 2000, Cristau, Michele; Devin, Chantal; Oiry, Catherine; Chaloin, Olivier; Amblard, Muriel; Bernad, Nicole; Heitz, Annie; Fehrentz, Jean-Alain; Martinez, Jean published an article in Journal of Medicinal Chemistry. The article was 《Synthesis and biological evaluation of bombesin constrained analogs》. The article mentions the following:
Analogs of bombesin which incorporate dipeptide or turn mimetics have been synthesized. One of them, peptide I containing a seven-membered lactam ring revealed a good affinity for GRP/BN receptors on rat pancreatic acini (Ki = 1.7 ± 0.4 nM) and on Swiss 3T3 cells (Ki = 1.0 ± 0.2 nM). On the basis of this observation, antagonists containing the same dipeptide mimic were obtained by modification of the C-terminal part of the bombesin analogs. The most potent constrained peptides II and III (pHPPA = p-hydroxy-3-phenylpropionyl) were able to antagonize 1 nM bombesin-stimulated amylase secretion from rat pancreatic acini with high potency (Ki = 21 ± 3 and 3.3 ± 1.0 nM, resp.) and 10-7 M bombesin-stimulated [3H]thymidine incorporation into Swiss 3T3 cells (Ki = 7.8 ± 2.0 and 0.5 ± 0.1 nM, resp.). In the experimental materials used by the author, we found (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Name: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide)
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Name: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics