In 2017,Tamanini, Emiliano; Buck, Ildiko M.; Chessari, Gianni; Chiarparin, Elisabetta; Day, James E. H.; Frederickson, Martyn; Griffiths-Jones, Charlotte M.; Hearn, Keisha; Heightman, Tom D.; Iqbal, Aman; Johnson, Christopher N.; Lewis, Edward J.; Martins, Vanessa; Peakman, Torren; Reader, Michael; Rich, Sharna J.; Ward, George A.; Williams, Pamela A.; Wilsher, Nicola E. published 《Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP)》.Journal of Medicinal Chemistry published the findings.Formula: C4H9NO2 The information in the text is summarized as follows:
XIAP and cIAP1 are members of the inhibitor of apoptosis protein (IAP) family and are key regulators of anti-apoptotic and pro-survival signaling pathways. Overexpression of IAPs occurs in various cancers and has been associated with tumor progression and resistance to treatment. Structure-based drug design (SBDD) guided by structural information from X-ray crystallog., computational studies, and NMR solution conformational anal. was successfully applied to a fragment-derived lead resulting in AT-IAP, a potent, orally bioavailable, dual antagonist of XIAP and cIAP1 and a structurally novel chem. probe for IAP biol. In the experiment, the researchers used many compounds, for example, N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2)
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Formula: C4H9NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics