In 2018,Journal of Medicinal Chemistry included an article by Gerasyuto, Aleksey I.; Arnold, Michael A.; Wang, Jiashi; Chen, Guangming; Zhang, Xiaoyan; Smith, Sean; Woll, Matthew G.; Baird, John; Zhang, Nanjing; Almstead, Neil G.; Narasimhan, Jana; Peddi, Srinivasa; Dumble, Melissa; Sheedy, Josephine; Weetall, Marla; Branstrom, Arthur A.; Prasad, J. V. N.; Karp, Gary M.. Computed Properties of C4H9NO2. The article was titled 《Discovery and Optimization of Indolyl-Containing 4-Hydroxy-2-Pyridone Type II DNA Topoisomerase Inhibitors Active against Multidrug Resistant Gram-negative Bacteria》. The information in the text is summarized as follows:
There exists an urgent medical need to identify new chem. entities (NCEs) targeting multidrug resistant (MDR) bacterial infections, particularly those caused by Gram-neg. pathogens. 4-Hydroxy-2-pyridones represent a novel class of nonfluoroquinolone inhibitors of bacterial type II topoisomerases active against MDR Gram-neg. bacteria. Herein, authors report on the discovery and structure-activity relationships of a series of fused indolyl-containing 4-hydroxy-2-pyridones with improved in vitro antibacterial activity against fluoroquinolone resistant strains. Compounds 10-((sec-butylamino)methyl)-4-hydroxy-9-methyl-2-oxo-2,5,6,9-tetrahydro-1H-pyrido[2′,3′:4,5]oxepino[3,2-f]indole-3-carboxylic acid hydrochloride (6o) and 4-hydroxy-9-methyl-2-oxo-10-(pyrrolidin-1-ylmethyl)-1,2,5,6,7,9-hexahydropyrido[3′,2′:6,7]cyclohepta[1,2-f]indole-3-carboxylic acid hydrochloride (6v) are representative of this class, targeting both bacterial DNA gyrase and topoisomerase IV (Topo IV). In an abbreviated susceptibility screen, compounds 6o and 6v showed improved MIC90 values against Escherichia coli (0.5-1 μg/mL) and Acinetobacter baumannii (8-16 μg/mL) compared to the precursor compounds In a murine septicemia model, both compounds showed complete protection in mice infected with a LD of E. coli. In the experimental materials used by the author, we found N-Methoxy-N-methylacetamide(cas: 78191-00-1Computed Properties of C4H9NO2)
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Computed Properties of C4H9NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics