《Solubility and partitioning. I: Solubility of nonelectrolytes in water》 was written by Yalkowsky, Samuel H.; Valvani, Shri C.. HPLC of Formula: 4746-61-6 And the article was included in Journal of Pharmaceutical Sciences on August 31 ,1980. The article conveys some information:
Semiempirical anal. gave an equation that enables the estimation of the aqueous solubility of either liquid or crystalline organic nonelectrolytes: log Sw ≈ -1.00 log PC – 1.11[ΔSf(MP-25)/1364] + 0.54 where log PC and ΔSf are estimated from the chem. structure and MP is either known or exptl. determined Anal. of this equation provides a means of assessing the role of crystal structure [as reflected by the m.p. (MP) and the entropy of fusion (ΔSf)] and of the activity coefficient [as reflected by the octanol-water partition coefficient (PC)] in controlling the aqueous solubility of a drug. Techniques are also provided for estimating the entropy of fusion of organic compounds In the experiment, the researchers used many compounds, for example, 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6HPLC of Formula: 4746-61-6)
2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides.HPLC of Formula: 4746-61-6 Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics