Hou, Hongcen; Zhao, Yongli; Sheng, Shouri; Chen, Junmin published the artcile< Iridium-Catalyzed ortho-C-H Amidation of Benzenesulfonamides with Sulfonyl Azides>, Safety of o-Chlorobenzenesulfonamide, the main research area is aminobenzesulfonamide preparation regioselective; benzenesulfonamide sulfonyl azide amidation iridium catalyst.
An iridium-catalyzed direct C-H activation/C-N bond formation reaction of benzenesulfonamides RS(O)2NHR1 (R = Ph, 2-methyl-4-fluorophenyl, 3-chlorophenyl, etc.) with sulfonyl azides R2C6H4S(O)2N3 (R2 = H, 4-Me, 2-Me, 4-OMe) was developed. The amidation reaction provides a protocol for the synthesis of 2-aminobenzenesulfonamides I (R3 = H, 2-Me-4-F, 3-Cl, 4-Ph, etc.) in good to excellent yields. This strategy features a wide substrate scope, tolerates a broad range of functional groups under external oxidant-free conditions and only releases mol. nitrogen as the sole byproduct. Moreover, the preliminary mechanism was investigated and the proposed reaction pathway was provided.
Advanced Synthesis & Catalysis published new progress about Amidation (C-H, regioselective). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Safety of o-Chlorobenzenesulfonamide.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics