Hou, Yunlei; Wu, Shasha; Ma, Longsheng; Bai, Jinying; Liu, Zijian; Zhao, Yanfang published the artcile< Design, synthesis and antitumor activity of novel 6,7-dimethoxyquinazoline derivatives containing diaryl urea moiety>, Product Details of C9H12N2O3, the main research area is sorafenib dimethoxyquinazoline diaryl urea scaffold antitumor lung gastric cancer.
A series of 6,7-dimethoxyquinazoline derivatives connected by diaryl urea scaffolds was designed, synthesized and their in vitro antitumor activities were evaluated. Most of them showed an excellent potency against the four tested cancer cell lines as compared with sorafenib. Particularly, a promising compound 20 was identified, which showed the most potent antitumor activities with IC50 values of 0.08, 0.09, 0.16 and 0.19 μmol/L against H460, HT-29, MKN-45 and MDA-MB-231 cell lines, resp. The structure-activity relationship(SAR) anal. indicated that compounds with dimethylamino or diethylamino group at the C4 position of 6,7-dimethoxyquinazoline moiety exhibited superior activities than compounds bearing morpholino groups.
Chemical Research in Chinese Universities published new progress about Antitumor agents. 5004-88-6 belongs to class amides-buliding-blocks, and the molecular formula is C9H12N2O3, Product Details of C9H12N2O3.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics