Hou, Hongcen; Zhao, Yongli; Pu, Shouzhi; Chen, Junmin published the artcile< Rhodium-catalyzed direct C-H bond alkynylation of aryl sulfonamides with bromoalkynes>, Application of C6H6ClNO2S, the main research area is alkynyl benzenesulfonamide preparation; aryl sulfonamide bromoalkyne mono alkynylation rhodium catalyst; benzosultam preparation; bromoalkyne aryl sulfonamide alkynylation intramol cyclization cascade rhodium catalyst.
An efficient protocol for the synthesis of ortho-(1-alkynyl)benzenesulfonamides I [R = H, 4-Me, 4-OCF3, etc.] was developed via rhodium-catalyzed direct ortho-mono-alkynylation of aryl sulfonamides with triisopropylsilyl (TIPS)-substituted bromoalkyne. While triethylsilyl or trimethylsilyl (TES or TMS)-substituted bromoalkyne was also amenable to the alkynylation, affording six membered benzosultams II [R1 = TMS, TES; R2 = H, 6-Me, 6-Et, 6-OMe] via the alkynylation/intramol. cyclization cascade reaction. The present protocol displayed high functional group tolerance and broad substrate scope under an air atm. in good to high yields. Mechanistic studies indicated that the reaction proceeded by a turnover limiting C-H activation step and a plausible mechanism was proposed.
Organic & Biomolecular Chemistry published new progress about Alkynes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6961-82-6 belongs to class amides-buliding-blocks, and the molecular formula is C6H6ClNO2S, Application of C6H6ClNO2S.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics