Chhajed, Priyanka N.; Garud, Aniket A.; Kakde, A. P.; Chaudhari, S. R.; Patil, Ravindra B. published the artcile< Anatomization of diabetes and its current marketed pharmacophores for its better indulgent>, Quality Control of 94-20-2, the main research area is diabetes antidiabetic.
Diabetes mellitus is a chronic disease that requires life-long pharmacol. and non-pharmacol. management to prevent complications such as cardiovascular disease, retinopathy, nephropathy, and neuropathy. While type 2 diabetes mellitus is the most common form of diabetes comprising of 90% to 95% of all diabetes cases. Its prevalence is constantly increasing and has already reached epidemic proportions, particularly in urban India. Currently available sulfonylurea’s (SU), the most commonly used pharmacol. agents in treatment of type 2 diabetes; have gradually increasing secondary failure rates reaching 50% at the end of 5 years of disease, though the initial response is good in 70-75% of patients. The biguanides are mainly used as adjuvant to sulfonylureas. The gastrointestinal intolerance limits their use in many patients. Thus, large number of patients with type 2 diabetes fails to achieve persistent good metabolic control. The limitations of currently available pharmacol. agents for control of blood glucose have stimulated research on novel anti-diabetic agents with different mechanism of action. The newer drugs already developed or in the process of development for management of type 2 diabetes are GLP-1 Receptor Agonists, DPP-4 Inhibitors, SGLT-2 Inhibitors, and Glucokinase activators.
Pharma Science Monitor published new progress about Autonomic neuropathy. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Quality Control of 94-20-2.
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