Wijaya, Mely; Subandi published the artcile< In silico analysis of saponin isolates from mesocarp of cucumber (Cucumic sativus L.) and purple eggplant (Solanum melongena L.) as pancreatic lipase inhibitor>, Related Products of 96829-58-2, the main research area is Cucumic Solanum mesocarp anti obesity pancreatic lipase inhibitor.
Currently orlistat has been widely used as anti-obesity drug, because of its activity as a pancreatic lipase inhibitor. Two saponin isolates, from cucumber mesocarp and purple eggplant, also proved to be active as pancreatic lipase inhibitors in vitro. Based on spectrophotometric anal., the two saponin isolates are thought to be Silphioside F and Cesdiurins I-III. The purpose of this study is to confirm the ability of the two compounds as pancreatic lipase inhibitor through in silico anal., relative to orlistat. This study uses Python Mol. Viewer (PyMol), Python Prescription (PyRx) 0.8, and Discovery Studio software. As a ligand, 3D structure of Silphioside F and Cesdiurins I-III have been used. The orlistat as a comparative ligand mol. have also been used. 3D structure of porsine pancreatic lipase has been used as receptor mol. The result of the anal. shown that the binding site of pancreatic lipase is relatively same as orlistat of Cesdiurins I-III mol., but different for the Silphioside F mol. The data indicated that in inhibiting pancreatic lipase, the two isolate compounds used different mechanism. However, against pancreatic lipase, both mols. have greater binding affinities each, compared to orlistat, which were -9.7 kcal/mol for Silhphioside F and -9.5 kcal/mol for Cesdiurins I-III, and orlistat only -7.6 kcal/mol. The latest data were in line with the in vitro anal., that both isolates have greater inhibition power than orlistat.
IOP Conference Series: Materials Science and Engineering published new progress about Antiobesity agents. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Related Products of 96829-58-2.
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