《Hydrogen-bonding one-dimensional arrangement in the crystal of N-phenyl-2-hydroxyacetamide》 was written by Perpetuo, Genivaldo Julio; Janczak, Jan. Application of 4746-61-6 And the article was included in Journal of Molecular Structure on August 27 ,2009. The article conveys some information:
The N-phenyl-2-hydroxyacetamide was obtained in crystalline form by a direct reaction of aniline with glycolic acid. The whole mol. in the crystal is nonplanar, but the planar 2-hydroxyacetamide group is inclined by 7.8(1)° to the plane of the Ph ring that is cis located to the carbonyl oxygen atom. The hydroxyl group is in trans position to the carbonyl oxygen atom. The mols. are linked by the N-H···O and O-H···O hydrogen bonds into 1-dimensional chains along the a-axis. Addnl., the C-H···π interactions interconnect the chains stabilizing the crystal structure. The x-ray geometry of the N-phenyl-2-hydroxyacetamide mol. was compared with that obtained by the ab-initio MO calculated results that represents the geometry in the gas-phase. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Application of 4746-61-6)
2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Application of 4746-61-6
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics