《Introduction of the amide function into 1,3,2-dioxaphospholenes with pentavalent phosphorus》 was published in Journal of the American Chemical Society in 1970. These research results belong to Ramirez, Fausto; Bauer, J.; Telefus, C. David. Application In Synthesis of 2-Hydroxy-N-phenylacetamide The article mentions the following:
Carbamoyl-1,3,2-dioxaphospholenes with pentavalent P were synthesized from α-oxo aldehydes, isocyanates, and trialkyl phosphites. The phospholenes were converted into phosphate esters of β-oxo-α-hydroxyamides. These underwent rapid hydrolyses to β-oxo-α-hydroxyamides. The experimental process involved the reaction of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Application In Synthesis of 2-Hydroxy-N-phenylacetamide)
2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole. The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors.“,” In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well. Application In Synthesis of 2-Hydroxy-N-phenylacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics