Saito, Takanobu; Caner, Joaquim; Toriumi, Naoyuki; Iwasawa, Nobuharu published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Rhodium-Catalyzed meta-Selective C-H Carboxylation Reaction of 1,1-Diarylethylenes via Hydrorhodation-Rhodium Migration》.COA of Formula: C4H9NO2 The article contains the following contents:
A meta-selective C-H carboxylation reaction of 1,1-diarylethylene derivatives with CO2 by using a rhodium catalyst with NaOiPr as a stoichiometric reductant has been achieved. Together with hydrogenation of the ethylene moiety, a carboxyl group was introduced to the meta-position of the aryl ring with high selectivity over the ortho-positions. Exptl. and computational mechanistic studies indicate that this carboxylation reaction proceeds via hydrorhodation on the ethylene moiety, followed by 1,4-rhodium migration and successive 1,2-rhodium migration on the aryl ring. The use of a bulky phosphine ligand seems to be the key to this unusual aryl-to-aryl 1,2-rhodium shift. The experimental process involved the reaction of N-Methoxy-N-methylacetamide(cas: 78191-00-1COA of Formula: C4H9NO2)
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.COA of Formula: C4H9NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics