SDS of cas: 106392-48-7On March 25, 1988, Shiraishi, Tadayoshi; Kameyama, Keiji; Imai, Naohiro; Domoto, Takeshi; Katsumi, Ikuo; Watanabe, Kiyoshi published an article in Chemical & Pharmaceutical Bulletin. The article was 《Specific inhibitors of tyrosine-specific protein kinase. I. Synthesis and inhibitory activities of α-cyanocinnamamides》. The article mentions the following:
A series of α-cyanocinnamamide derivatives was synthesized and evaluated for inhibitory activity against tyrosine-specific protein kinase of intact plasma membrane fractions from an epidermoid carcinoma cell line, A-431. Among these compounds, several novel α-cyano-4-hydroxy-3,5-disubstituted cinnamamide derivatives, e.g., ST 638 (I) showed potent inhibitory activity. The studies on the structure-activity relationship revealed that the presence of the OH group at the 4 position and the double bond in the α-cyano-4-hydroxycinnamamide skeleton were important for potent inhibitory activity, and that the presence of hydrophobic groups at the 3 and 5 positions on the benzene ring also enhanced the inhibitory activity of α-cyano-4-hydroxycinnamamide derivatives In the experimental materials used by the author, we found 2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(cas: 106392-48-7SDS of cas: 106392-48-7)
2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(cas: 106392-48-7) belongs to amides.SDS of cas: 106392-48-7 The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics