Category: amides-buliding-blocksIn 2021 ,《Synthesis and Applications of Polysubstituted Bicyclo[1.1.0]butanes》 appeared in Journal of the American Chemical Society. The author of the article were McNamee, Ryan E.; Thompson, Amber L.; Anderson, Edward A.. The article conveys some information:
The synthesis of tri- and tetrasubstituted bicyclo[1.1.0]butanes (BCBs) via directed metalation of readily accessed BCB amides is reported. This straightforward “”late stage”” approach generates a wide variety of bridge-substituted BCBs that was easily converted into other useful small ring building blocks. Access to a monodeuterated BCB provides an unprecedented insight into the mechanism of dihalocarbene insertion into BCBs to afford bicyclo[1.1.1]pentanes. In the experiment, the researchers used N-Methoxy-N-methylacetamide(cas: 78191-00-1Category: amides-buliding-blocks)
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics