Jin, Pengfei; Xu, Shuo; Xu, Wenfeng; He, Xiaorong; Kuang, Yongmei; Hu, Xin published the artcile< Screening and quantification of fourteen synthetic antidiabetic adulterants in herbal pharmaceuticals and health foods by HPLC and confirmation by LC-Q-TOF-MS/MS>, Formula: C10H13ClN2O3S, the main research area is antidiabetic adulterant herbal pharmaceutical; HPLC; Q-TOF; adulterant; antidiabetic; health food; herbal pharmaceutical.
A procedure was established and fully validated for the screening and quantification of fourteen synthetic antidiabetic adulterants in herbal pharmaceuticals and health foods, including metformin (MF), buformin (BF), phenformin (PHF), rosiglitazone (RGZ), pioglitazone (PGZ), chlorpropamide (CPM), glipizide (GPZ), tolbutamide (TBM), gliclazide (GCZ), glibenclamide (GBM), glimepiride (GMR), repaglinide (RGN), gliquidone (GQD) and nateglinide (NGN). The samples were extracted by methanol and separated by HPLC. Retention times and UV spectra were used for the preliminary screening, and the suspected adulterants were then confirmed by liquid chromatog.-quadrupole-time of flight mass spectrometry (LC-Q-TOF-MS/MS) and quantified by HPLC. The developed procedure was successfully applied to assess twenty-four herbal samples, and PHF, GCZ, GBM, MF, GPZ and BF were found in many. To the best of our knowledge, this is the first report of simultaneous screening and quantification of these fourteen synthetic antidiabetic adulterants from any matrix.
Food Additives & Contaminants, Part A published new progress about Drug stability. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Formula: C10H13ClN2O3S.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics