Khedr, Naglaa F.; Ebeid, Abla M.; Khalil, Rania M. published the artcile< New insights into weight management by orlistat in comparison with cinnamon as a natural lipase inhibitor>, Reference of 96829-58-2, the main research area is obesity orlistat cinnamon weight management; Cinnamon; Dopamine; Dyslipidemia; Glutamate; Obesity; Orlistat.
Background and objectives: Orlistat which is taken by obese patients may present some therapeutic assistance through its inhibition of lipase activity. Otherwise, a natural lipase inhibitor as cinnamon is widely used traditional medicine to decrease cholesterol and body weight The current study aimed to investigate the weight management of orlistat in comparison with cinnamon through different obesity related targets. Methods: Subjects were divided into: Group 1: subjects received cinnamon capsules for 60 days. Results: Both orlistat and cinnamon groups showed a significant reduction in BMI, lipid profile, and lipase activity compared with baseline. Orlistat group showed significant elevation (p < 0.001) in glucagon, insulin-degrading enzyme (IDE) and dopamine level concomitant with the decrease of serum glutamate compared with baseline level of the same group and cinnamon group. However, cinnamon reduced serum insulin level and insulin resistance (IR) compared with baseline level of the same group and orlistat group. Conclusions: Orlistat can be used in weight management not only for its pancreatic lipase inhibition but also, due to its indirect appetite reduction effect through elevated glucagon, IDE and dopamine levels and its inhibitory effect on glutamate neurotransmitter, whereas, cinnamon improves BMI and glycemic targets. Endocrine published new progress about Blood serum. 96829-58-2 belongs to class amides-buliding-blocks, and the molecular formula is C29H53NO5, Reference of 96829-58-2.
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