Synthetic Route of 2835-68-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2835-68-9 name is 4-Aminobenzamide, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: To a solution of amine (1 mmol) in water (2 ml) was added tetrahydro-2,5-dimethoxyfuran (1.1 mmol) and gamma-Fe2O3(at)SiO2-Sb-IL (0.08 g). The reaction mixture was stirred at 100 C for a certain period of time as required to complete the reaction. During that time, the reaction was monitored constantly by TLC. After completion of the reaction, the catalyst was removed by using a magnet and washed with ethyl acetate. The aqueous solution was extracted by ethyl acetate (3 ¡Á 5 ml). The combined organic phase was dehydrated with anhydrous sodium sulfate. After the evaporation of the solvent, the residue was purified by silica gel flash chromatography using petroleum ether/ethyl acetate as the eluent to afford the pure product. 4-(1H-Pyrrol-1-yl)benzamide (3an). IR (KBr): 3142, 1645, 1613, 1577, 1525, 1475, 1425, 1394, 1327, 1199, 1120, 1064, 1014, 920, 846, 723 cm-1; 1H NMR (CDCl3, 500 MHz) delta: 6.39 (t, J = 2.0 Hz, 2H), 7.16 (t, J = 2.0 Hz, 2H), 7.47(d, J = 8.5 Hz, 2H), 7.89 (d, J = 8.5 Hz, 2H) ppm; 13C NMR (CDCl3, 125 MHz) delta: 111.4, 119.1, 119.7, 130.0, 129.1,143.4, 168.2 ppm; ESI-MS: m/z = 187 (M + 1)+; Anal. Calcd. for C11H10N2O: C, 70.95; H, 5.41; N, 15.04. Found: C, 71.12; H, 5.60; N, 14.86.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Aminobenzamide, and friends who are interested can also refer to it.
Reference:
Article; Ma, Fei-Ping; Li, Pei-He; Li, Bao-Le; Mo, Li-Ping; Liu, Ning; Kang, Hui-Jun; Liu, Ya-Nan; Zhang, Zhan-Hui; Applied Catalysis A: General; vol. 457; (2013); p. 34 – 41;,
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics