Irigoyen, Sonia; Ramasamy, Manikandan; Pant, Shankar; Niraula, Prakash; Bedre, Renesh; Gurung, Meena; Rossi, Denise; Laughlin, Corinne; Gorman, Zachary; Achor, Diann; Levy, Amit; Kolomiets, Michael V.; Setamou, Mamoudou; Badillo-Vargas, Ismael E.; Avila, Carlos A.; Irey, Michael S.; Mandadi, Kranthi K. published the artcile< Plant hairy roots enable high throughput identification of antimicrobials against Candidatus Liberibacter spp.>, Electric Literature of 94-20-2, the main research area is antimicrobial hairy root disease Candidatus.
A major bottleneck in identifying therapies to control citrus greening and other devastating plant diseases caused by fastidious pathogens is our inability to culture the pathogens in defined media or axenic cultures. As such, conventional approaches for antimicrobial evaluation (genetic or chem.) rely on time-consuming, low-throughput and inherently variable whole-plant assays. Here, we report that plant hairy roots support the growth of fastidious pathogens like Candidatus Liberibacter spp., the presumptive causal agents of citrus greening, potato zebra chip and tomato vein greening diseases. Importantly, we leverage the microbial hairy roots for rapid, reproducible efficacy screening of multiple therapies. We identify six antimicrobial peptides, two plant immune regulators and eight chems. which inhibit Candidatus Liberibacter spp. in plant tissues. The antimicrobials, either singly or in combination, can be used as near- and long-term therapies to control citrus greening, potato zebra chip and tomato vein greening diseases.
Nature Communications published new progress about Antimicrobial agents. 94-20-2 belongs to class amides-buliding-blocks, and the molecular formula is C10H13ClN2O3S, Electric Literature of 94-20-2.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics